Tuesday, October 25, 2016

Amiloride and Hydrochlorothiazide

Generic Name : Amiloride and Hydrochlorothiazide

Pronunciation : a mill' oh ride - hye droe klor oh thye' a zide

Trade Name(s): 
India- Amilochlor Tab , Biduret Tab , Biduret-L Tab.
International- Moduretic.


Why it is prescribed (Indications) : 
This combination medication contains diuretics, prescribed for hypertension and congestive heart failure.




When it is not to be taken (Contraindications): 


Contraindicated in patients with kidney impairment, increased level of potassium in blood and pregnancy.





Pregnancy Category :













A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.


When it is to be taken : 
Adult: PO- Per tab contains amiloride 5 mg and hydrochlorothiazide 50 mg: 1-2 tab/day.


How it should be taken : 
It comes as a tablet to take by mouth, with food.




Special Instruction : 
* Caution should be exercised in patients with history of untreated salt/mineral imbalance (such as high potassium, low sodium level), kidney disease, liver disease, diabetes, loss of water content in body (dehydration), lupus, gout, high levels of fat content in blood, any allergy, who are taking other medications, during pregnancy and breastfeeding.


* It may cause dizziness or lightheadedness, do not drive a car or operate machinery, and get up slowly from bed while taking this medication.


* Avoid alcohol consumption.


* Monitor blood sugar regularly while taking this medication.


Side Effects : 
Body as a Whole -

Headache, weakness and fatigue/tiredness.
Heart -

Irregular heart rate.
Gastrointestinal -

Nausea/loss of appetite, diarrhea, gastrointestinal pain and abdominal pain.
Metabolic -

Elevated serum potassium levels.
Musculoskeletal -

Leg pain.
Nervous system -

Dizziness.
Respiratory -

Difficulty in breathing.
Skin -

Rash and itching.


Other Precautions : 
* Avoid excess dosage.


* Avoid long-term use of this medication; otherwise it may lead to increase level of potassium in blood.


Storage Conditions : 
Store it at room temperature (15-30°C), and in an airtight container. Keep away from children.



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