Generic Name : Eptifibatide
Pronunciation : ep-ti-FIB-ih-tide
Trade Name(s):
India- Antigrilin Inj, Clotide Vial, Coromax Inj, Fleta Bolus Infusion Bag.
International- Integrilin.
Why it is prescribed (Indications) :
This medication is an antithrombotic agent, prescribed for the treatment of patients with acute coronary syndrome (heart condition), and those undergoing percutaneous coronary intervention (angioplasty), and stenting (placing of a cylindrical device within vessels). It prevents platelets in the blood from sticking to each other.
When it is not to be taken (Contraindications):
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
When it is to be taken :
Intravenous-
Unstable angina(acute coronary syndrome)-
Adult: 180 mcg/kg via IV injection followed by 2 mcg/kg/minute by IV infusion for up to 72 hours. If percutaneous coronary intervention is performed during therapy, infusion should be continued for 18-24 hours after procedure, up to a max total duration of 96 hours of therapy.
How it should be taken :
It will be administered as an injection at a hospital.
Special Instruction :
*Discontinue in case of serious uncontrolled bleeding, or if emergency surgery or thrombolytic (drugs are used in medicine to dissolve blood clots) therapy is required.
*Caution should be exercised in patients with liver impairment, platelet counts
*Check aPTT [activated partial thromboplastin time or ACT(activated clotting time) prior to sheath removal during angioplasty.
*It may lead to severe kidney impairment, inflammation of blood vessels, bleeding in the eye, acute pericardial inflammation ( inflammation of the covering of the heart)or aortic dissection (splitting of the layers of the aorta leading to formation of outpouchings).
Side Effects :
Allergic Reactions-
Easy bruising or bleeding, pink or red-colored urine, black stool, coffee-ground vomit, one-sided weakness, vision problems, confusion, slurred speech.
Heart-
Low blood pressure.
Blood-
Reduced platelets, cerebral, GI, and lung bleeding, acute profound thrombocytopenia, fatal bleeding events.
Local-
Overall incidence of major bleeding, major bleeding.
Other Precautions :
*Monitor complete blood counts, serum creatinine levels regularly.
Storage Conditions :
Storage: Store at 25 °C. Store it in airtight container and keep away from children.
Pronunciation : ep-ti-FIB-ih-tide
Trade Name(s):
India- Antigrilin Inj, Clotide Vial, Coromax Inj, Fleta Bolus Infusion Bag.
International- Integrilin.
Why it is prescribed (Indications) :
This medication is an antithrombotic agent, prescribed for the treatment of patients with acute coronary syndrome (heart condition), and those undergoing percutaneous coronary intervention (angioplasty), and stenting (placing of a cylindrical device within vessels). It prevents platelets in the blood from sticking to each other.
When it is not to be taken (Contraindications):
Contraindicated in patients with increased risk of bleeding disorders, brain disorders, history of stroke, uncontrolled hypertension, severe injury, severe kidney impairment, recent major surgery, breastfeeding.
Pregnancy Category : |
|
When it is to be taken :
Intravenous-
Unstable angina(acute coronary syndrome)-
Adult: 180 mcg/kg via IV injection followed by 2 mcg/kg/minute by IV infusion for up to 72 hours. If percutaneous coronary intervention is performed during therapy, infusion should be continued for 18-24 hours after procedure, up to a max total duration of 96 hours of therapy.
How it should be taken :
It will be administered as an injection at a hospital.
Special Instruction :
*Discontinue in case of serious uncontrolled bleeding, or if emergency surgery or thrombolytic (drugs are used in medicine to dissolve blood clots) therapy is required.
*Caution should be exercised in patients with liver impairment, platelet counts
*Check aPTT [activated partial thromboplastin time or ACT(activated clotting time) prior to sheath removal during angioplasty.
*It may lead to severe kidney impairment, inflammation of blood vessels, bleeding in the eye, acute pericardial inflammation ( inflammation of the covering of the heart)or aortic dissection (splitting of the layers of the aorta leading to formation of outpouchings).
Side Effects :
Allergic Reactions-
Easy bruising or bleeding, pink or red-colored urine, black stool, coffee-ground vomit, one-sided weakness, vision problems, confusion, slurred speech.
Heart-
Low blood pressure.
Blood-
Reduced platelets, cerebral, GI, and lung bleeding, acute profound thrombocytopenia, fatal bleeding events.
Local-
Overall incidence of major bleeding, major bleeding.
Other Precautions :
*Monitor complete blood counts, serum creatinine levels regularly.
Storage Conditions :
Storage: Store at 25 °C. Store it in airtight container and keep away from children.
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