Wednesday, October 19, 2016

Rasagiline

Generic Name : Rasagiline

Pronunciation : ra sa' ji leen

Trade Name(s): 
India- Relgin.
International- Azilect.


Why it is prescribed (Indications) : 
This medication is an irreversible inhibitor of monoamine oxidase, prescribed for Parkinson’s disease either alone or with other medications. The medication elevates the levels of certain chemicals in brain.




When it is not to be taken (Contraindications): 


It should not be used with meperidine, antitussive agent dextromethorphan, with any other MAO inhibitor; Known hypersensitivity.





Pregnancy Category :












A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
PO- The recommended dose is 0.5 or 1 mg daily.

How it should be taken : 
It comes as a tablet to take by mouth.




Special Instruction : 
* Caution should be exercised in patients with history of high blood pressure, skin cancer, mental illness or psychosis; kidney, or liver disease, during pregnancy and breastfeeding.



* It may cause dizziness, drowsiness, lightheadedness, get up slowly from bed; avoid driving or any other harmful activities.



* It may cause an increase in blood pressure, monitor blood pressure level regularly.

Side Effects : 
Heart-

Chest pain and fainting.
Central Nervous System-

Headache, depression, weakness, tingling, fainting, hallucinations, abnormal gait, anxiety, decreased libido, dizziness, restlessness, nerve disease and tremor.
Skin-

Hair loss, skin cancer and rash.
Eye and ENT-

Inflammation of eye and nose.
Gastrointestinal-

Indigestion, stomach inflammation, loss of appetite, diarrhea, GI bleeding and vomiting.
Genitourinary-

Presence of albumin in urine, blood in urine, impotence and urinary incontinence.
Blood-

Bruising and decrease in white blood cells.
Liver-

Abnormal liver function.
Musculoskeletal-

Joint inflammation/pain, arthritis and neck pain.
Respiratory-

Asthma and increased cough.
Miscellaneous-

Falling, flu syndrome, fever, allergic reaction and chest pain.

Other Precautions : 
* Patient may develop with an increased risk of skin cancer, if it so, consult with your doctor.

Storage Conditions : 
Store it at room temperature (25°C), and in an airtight container. Keep away from children.


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